KYA1797K New
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CAS No. | 1956356-56-1 | Cat. No. | BCP29963 |
Name | KYA1797K | ||
Synonyms | KYA1797K potassium salt; | ||
SMILES | C1=CC(=CC=C1C2=CC=C(O2)C=C3C(=O)N(C(=S)S3)CCC(=O)[O-])[N+](=O)[O-].[K+] | ||
Chemical Name | |||
Formula | C17H11N2O6S2.K | M. Wt | 442.50 |
Purity | 98% | Storage | Store at 4-8°C |
Description | KYA1797K is an inhibitor of both Wnt/β-catenin and Ras pathways. It binds to the axin regulators of the G-protein signaling (RGS) domain enhancing formation of the β-catenin destruction complex and inducing activation GSK3β, which results in phosphorylation and subsequent degradation of both β-catenin and K-Ras. KYA1797K was show to suppress tumor growth and progression in mouse xenografts of CRC cells that had APC and K-Ras mutations. |
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