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CAS No. | 1979939-16-6 | Cat. No. | BCP42590 |
Name | CRT0273750 | ||
Synonyms | CRT 0273750; CRT-0273750; | ||
SMILES | CC(C1=CC=C(C=C1)Cl)NC(=O)CCC2=NC3=C(N2CC4=CC=C(C=C4)OC(F)(F)F)N=CC=C3 | ||
Chemical Name | |||
Formula | C25H22ClF3N4O2 | M. Wt | 502.92 |
Purity | 98% | Storage | Store at 4-8°C |
Description | CRT0273750 is an autotaxin inhibitor. CRT0273750 modulates LPA levels in plasma and is suitable for in vivo studies. CRT0273750 has an unexpected binding mode in that they do not interact with the active site zinc ions but instead occupy the hydrophobic LPC pocket extending from the active site of ATX together with occupying the LPA 'exit' channel. |
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