ADH-503choline New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2055362-74-6 | Cat. No. | BCP44165 |
| Related Products | 2055362-72-4（ADH503） | ||
| Name | ADH-503choline | ||
| Synonyms | ADH 503; ADH503; Leukadherin-1 choline salt; | ||
| SMILES | C[N+](C)(C)CCO.C1=CC=C(C=C1)CN2C(=O)C(=CC3=CC=C(O3)C4=CC=C(C=C4)C(=O)[O-])SC2=S | ||
| Chemical Name | |||
| Formula | C27H28N2O5S2 | M. Wt | 524.65 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ADH-503 is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression. The partial activation of CD11b by ADH-503 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhanced dendritic cell responses. These actions, in turn, improve antitumor T cell immunity and render checkpoint inhibitors effective in previously unresponsive PDAC models. | ||
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