K-Ras(G12C) inhibitor 6 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2060530-16-5 | Cat. No. | BCP30805 |
| Name | K-Ras(G12C) inhibitor 6 | ||
| Synonyms | MDK30165; MDK-30165; MDK 30165; | ||
| SMILES | C1CN(CCC1NC(=O)CCCS)C(=O)COC2=C(C=C(C=C2)Cl)Cl | ||
| Chemical Name | |||
| Formula | C17H22Cl2N2O3S | M. Wt | 405.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant. K-Ras (G12C) inhibitor 6 is a cysteine-reactive small molecule. It irreversibly binds to the G12C mutantion of GTPase K-Ras but not the wild-type K-Ras with the relative potency value of 4.2. The binding pocket of K-Ras for K-Ras (G12C) inhibitor 6 is a new allosteric pocket, S-IIP. Binding of this pocket results in a change of the relative nucleotide affinity of Ras to favour GDP over GTP, leading to an accumulation of inactive Ras. Since the mutation of K-Ras is quite common in human cancers, the inhibitor of K-Ras G12C should exert suppression activities in tumor cells. It has been reported that, some of the K-Ras G12C inhibitors are indeed effective to decrease cell viability and increase apoptosis in lung cancer cell lines. | ||
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