OATD-01 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2088453-21-6 | Cat. No. | BCP44134 |
| Name | OATD-01 | ||
| Synonyms | OATD 01; OATD01; GLPG-4716; GLPG 4716; GLPG4716; | ||
| SMILES | CC1CN(C(CO1)CC2=CC=C(C=C2)Cl)C3CCN(CC3)C4=NNC(=N4)N | ||
| Chemical Name | |||
| Formula | C19H27ClN6O | M. Wt | 390.91 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | OATD-01 is a potent and selective chitinase inhibitor for treatment of interstitial lung diseases. OATD-01 showed (hAMCase IC50=9nM, hCHIT1 IC50=26nM) significantly reduced lung fibrosis in the bleomycin-induced fibrosis model, comparably to nintedanib, as assessed by modified Ashcroft scoring. The anti-fibrotic activity of OATD-01 was associated with pharmacodynamic effect: plasma chitinolytic activity was significantly reduced in mice dosed with OATD-01 as compared to control group. | ||
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