RMC4550 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP30530CAS No. ：2172651-73-7Purity：98%

Size	Price	Stock	Quotation Inquiry
50.00 mg	Get quote	In-stock	Quotation Inquiry
100.00 mg	Get quote	In-stock	Quotation Inquiry
1.00 g	Get quote	In-stock	Quotation Inquiry

Get Quotation Now

Tel: 0086-13026320035 or orders@biochempartner.com

* Required Fields.

Please complete the form below and you will get the price list in 1 minute.

* Required Fields.

Please complete the form below and we will contact you shortly.

* Required Fields.

Please complete the form below and we will contact you shortly.

CAS No.	2172651-73-7	Cat. No.	BCP30530
Name	RMC4550
Synonyms	RMC 4550; RMC4550;
SMILES	CC1C(C2(CCN(CC2)C3=NC(=C(N=C3CO)C4=C(C(=CC=C4)Cl)Cl)C)CO1)N
Chemical Name
Formula	C21H26Cl2N4O2	M. Wt	437.36
Purity	98%	Storage	Store at 4-8°C
Description	RMC-4550 (RMC4550) is a potent, selective, allosteric inhibitor of SHP2 with IC50 of 0.58 nM (full-length SHP2 enzyme), suppresses pERK signaling in Calu-1 cells with IC50 of 7 nM; shows no activity against the SHP2 catalytic domain up to 10 uM, RMC-4550 is highly selective for full-length SHP2 across panels comprising 15 other phosphatases, 468 kinases, and 44 cellular targets; cancer cell lines bearing missense mutations in KRAS at G12, but neither G13 nor Q61, exhibit sensitivity to RMC-4550 (IC50<2 uM), suppresses growth and RAS/MAPK signaling in cancer cell lines with Class 3 BRAF mutations; inhibits tumor growth and RAS/MAPK signaling in xenograft models of KRASG12C-driven cancer.