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ANA-12 结构式

ANA-12

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货号 :BCP16021CAS号 :219766-25-3纯度:98%
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  • 基本信息与产品描述
CAS号 219766-25-3 货号 BCP16021
中文名 ANA-12
英文名 ANA-12
中文别名
英文别名 ANA12;ANA 12;
SMILES
化学名称
分子式 C22H21N3O3S 分子量 407.49
纯度 98% 配送 惯例下常温包邮
产品描述 in vitro: ANA-12 prevented activation of the receptor by BDNF with a high potency. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Saturation binding studies with TrkBECD-Fc showed that ANA-12 binds TrkBECD-Fc with a Kd of 12 μM [1]. The selective TrkB (tropomyosin-receptor-kinase) antagonist ANA-12 reduced OIH when given one or seven days after cessation of morphine. in vivo: Mice administered ANA-12 demonstrated reduced anxiety- and depression-related behaviors on a variety of tests predictive of anxiolytic and antidepressant properties in humans [1]. Administration of a BDNF receptor antagonist (the TrkB receptor antagonist ANA-12) reversed the diminished cocaine self-administration in male cocaine-sired rats.
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