TAK-779

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP28073CAS No. ：229005-80-5Purity：98%

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CAS No.	229005-80-5	Cat. No.	BCP28073
Name	TAK-779
Synonyms	TAK 779; TAK779;Takeda 779;Takeda-779;Takeda779;
SMILES	C[N+](C)(CC1=CC=C(NC(C2=CC3=CC(C4=CC=C(C)C=C4)=CC=C3CCC2)=O)C=C1)C5CCOCC5.[Cl-]
Chemical Name
Formula	C33H39N2O2.Cl	M. Wt	531.14
Purity	98%	Storage	Store at 4-8°C
Description	TAK-779 is a C-C chemokine receptor type 5 (CCR5) receptor antagonist potentially for the treatment of HIV infection. Treatment with TAK-779 reduced incidence and severity of experimental autoimmune encephalomyelitis. It strongly inhibited migration of CXCR3/CCR5 bearing CD4+, CD8+ and CD11b+ leukocytes to the CNS. TAK-779 did not reduce proliferation of anti-myelin oligodendrocyte glycoprotein T cells, the production of IFN-gamma by T cells or CXCR3 expression on T cells. In addition, TAK-779 did not affect production of IL-12 by antigen-presenting cells, CCR5 induction on T cells and the potential of myelin oligodendrocyte glycoprotein-specific T cells to transfer experimental autoimmune encephalomyelitis.