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SU-6668 结构式

SU-6668

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货号 :BCP01984CAS号 :252916-29-3纯度:98%
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  • 瀚香生物(Biochempartner)的SU-6668被文献引用
  • 基本信息与产品描述
CAS号 252916-29-3 货号 BCP01984
中文名 SU-6668
英文名 SU-6668
中文别名
英文别名 SU6668;TSU-68;SU 6668;
SMILES
化学名称
分子式 C18H18N2O3 分子量 310.35
纯度 98% 配送 惯例下常温包邮
产品描述 TSU-68 is a competitive inhibitor, with regard to ATP, to Flk-1/KDR trans-phosphorylation, FGFR1 trans-phosphorylation, and PDGFRβ kinases autophosphorylation. TSU-68 (0.03-10 μM) inhibits tyrosine phosphorylation of KDR in VEGF stimulated HUVECs. TSU-68 also inhibits PDGF-stimulated PDGFRβ tyrosine phosphorylation in NIH-3T3 cells overexpressing PDGFRβ at a minimum concentration of 0.03-0.1 μM. TSU-68 inhibits acidic FGF-induced phosphorylation of the FGFR1 substrate 2 at 10 μM and higher. However, TSU-68 (up to 100 μM) has no effect on EGF-stimulated EGFR tyrosine phosphorylation in NIH-3T3 cells overexpressing EGFR. TSU-68 inhibits VEGF-driven and FGF-driven mitogenesis of HUVECs with mean IC50 of 0.34 μM and 9.6 μM, respectively. In human myeloid leukemia MO7E cells, TSU-68 inhibits the tyrosine autophosphorylation of stem cell factor (SCF) receptor, c-kit, with IC50 of 0.1-1 μM, as well as ERK1/2 phosphorylation, a signaling event downstream of c-kit activation. TSU-68 also inhibi
  • 技术资料和支持
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