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NH125 Chemical Structure

NH125

Data Sheet For research use only. Not for human use.
Cat. No. :BCP29662CAS No. :278603-08-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 278603-08-0 Cat. No. BCP29662
Name NH125
Synonyms NH-125; NH 125;eEF-2 Kinase Inhibitor, NH125;
SMILES CCCCCCCCCCCCCCCCN1C=C[N+](=C1C)CC2=CC=CC=C2.[I-]
Chemical Name
Formula C27H45N2.I M. Wt 524.56
Purity 98% Storage Store at 4-8°C
Description NH125 is a Eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Decreases the viability of a variety of cancer cell lines (IC50 values are 0.7 - 4.8 μM) and blocks G1/S cell cycle progression. Shown to induce eEF-2 phosphorylation in cancer cells. Also an effective antibacterial agent; inhibits histidine protein kinase in vitro (IC50 = 6.6 μM) and in vivo.
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