HPI-4

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP18834CAS No. ：302803-72-1Purity：98%

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CAS No.	302803-72-1	Cat. No.	BCP18834
Name	HPI-4
Synonyms	CiliobrevinA;HPI 4;HPI4;Hedgehog Pathway Inhibitor 4;
SMILES
Chemical Name
Formula	C17H9Cl2N3O2	M. Wt	358.18
Purity	98%	Storage	Store at 4-8°C
Description	Ciliobrevin A, also known as HPI-4 and Hedgehog Pathway Inhibitor 4, is a Hedgehog pathway inhibitor. Treatment with HH pathway inhibitor-4 (HPI-4) could significantly decrease human chondrosarcoma cell proliferation, invasion and migration ability. Furthermore, HPI-4 could distinctly disturb HH pathway-mediated ciliogenesis and suppress primary cilia-related protein intraflagellar transport protein IFT88 expression. HH downstream effect molecular GLI2 was restrained to block parathyroid hormone-related protein and affect MAPK/ERK-regulated matrix metalloproteinases (MMP2 and MMP9). d HPI-4 could be a new therapeutic option specific to chondrosarcoma expressing elevated levels of HH pathway.