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SAICAR Chemical Structure

SAICAR

Data Sheet For research use only. Not for human use.
Cat. No. :BCP28964CAS No. :3031-95-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 3031-95-6 Cat. No. BCP28964
Name SAICAR
Synonyms Succino-AICAR; Succinyl-5-aminoimidazole-4-carboxamide-1-ribose-5'-phosphate;
SMILES O=C(O)C[C@@H](C(O)=O)NC(C1=C(N)N([C@H]2[C@@H]([C@@H]([C@@H](COP(O)(O)=O)O2)O)O)C=N1)=O
Chemical Name
Formula C13H19N4O12P M. Wt 454.28
Purity 98% Storage Store at 4-8°C
Description SAICAR, also known as Succino-AICAR, is an intermediate in the de novo purine nucleotide synthesis pathway. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells. SAICAR-mediated PKM2 protein kinase activity is necessary for EGF-induced cancer cell proliferation.
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