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Lofexidine Chemical Structure

Lofexidine

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP30596CAS No. ：31036-80-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 31036-80-3 Cat. No. BCP30596
Name Lofexidine
Synonyms Lofexidinum；Britlofex;
SMILES CC(C1=NCCN1)OC2=C(C=CC=C2Cl)Cl
Chemical Name
Formula C11H12Cl2N2O M. Wt 259.13
Purity 98% Storage Store at 4-8°C
Description Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992.[A33084] It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hypertension than clonidine.[T210] Lofexidine was then repurposed for the treatment of opioid withdrawal, as it was seen to be more economical and have fewer side effects than clonidine.
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