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PK11007 Chemical Structure

PK11007

Cat. No. :BCP30143CAS No. :38275-34-2Purity:98%
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Synonyms PK-11007; PK 11007
CAS Number 38275-34-2
Purity 98%
M. Wt 236.62
Formula C6H5ClN2O4S
Storage Store at 4-8°C
PK11007 is an anti-p53 drug. PK11007 stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding. PK11007 preferentially decreases viability in p53-compromised cancer cell lines. IC50 values for inhibition of proliferation in a panel of 17 breast cell lines by PK11007 ranged from 2.3 to 42.2 μM.

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