MarizoMib New
Data Sheet
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| CAS No. | 437742-34-2 | Cat. No. | BCP13082 |
| Name | MarizoMib | ||
| Synonyms | ML 858; ML-858; ML858; NPI 0052; NPI-0052; NPI0052; (-)-Salinosporamide A; Salinosporamide A; | ||
| SMILES | CC12C(C(=O)NC1(C(=O)O2)C(C3CCCC=C3)O)CCCl | ||
| Chemical Name | |||
| Formula | C15H20ClNO4 | M. Wt | 313.78 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Marizomib, also known as ML 858, NPI-0052 and Salinosporamide A, is a potent and selective 20S proteasome inhibitor from natural origin. Marizomib irreversibly inhibits proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients. Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brain barrier. Marizomib exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs. | ||
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