Cyclopamine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01796CAS No. ：4449-51-8Purity：98%

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CAS No.	4449-51-8	Cat. No.	BCP01796
Name	Cyclopamine
Synonyms	11-Deoxojervine;
SMILES	O[C@@H](CC[C@@]12C)CC1=CC[C@@]([H])([C@@]2(CC3=C4C)[H])[C@@]3(CC[C@@]54O[C@]6([H])C[C@@H](CN[C@]6([C@]5C)[H])C)[H]
Chemical Name
Formula	C27H41NO2	M. Wt	411.62
Purity	98%	Storage	Store at 4-8°C
Description	Cyclopamine, also known as 11-deoxojervine, is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog signaling pathway (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed. Cyclopamine was named for one-eyed lambs which were born to sheep which grazed on wild corn lily at a farm in Idaho.