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Tivozanib Chemical Structure

Tivozanib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01980CAS No. ：475108-18-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 475108-18-0 Cat. No. BCP01980
Related Products 682745-41-1（Tivozanib hydrochloride hydrate）
Name Tivozanib
Synonyms AV-951;AV951;AV 951; KRN951; KRN 951; KRN-951;
SMILES O=C(NC1=NOC(C)=C1)NC2=CC=C(OC3=CC=NC4=CC(OC)=C(OC)C=C34)C=C2Cl
Chemical Name
Formula C22H19ClN4O5 M. Wt 454.86
Purity 98% Storage Store at 4-8°C
Description Tivozanib, also known as KRN951, is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.
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H-NMR HPLC
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