ZSTK474
Data Sheet
For research use only. Not for human use.
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| CAS No. | 475110-96-4 | Cat. No. | BCP01867 |
| Name | ZSTK474 | ||
| Synonyms | ZSTK-474;ZSTK 474; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H21F2N7O2 | M. Wt | 417.42 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ZSTK474 is a novel orally applicable phosphoinositide 3-kinase-specific inhibitor that strongly inhibits cancer cell proliferation. Combination treatment using X-rays then ZSTK474 given orally for 8 days, starting 24h post-irradiation, significantly enhanced cell growth inhibition. The combined effect was also observed for clonogenic survival with continuous ZSTK474 treatment. Western blot analysis showed enhanced phosphorylation of Akt and GSK-3β by X-irradiation, whereas phosphorylation was inhibited by ZSTK474 treatment alone. Treatment with ZSTK474 after X-irradiation also inhibited phosphorylation, and remarkably inhibited xenograft tumor growth. | ||
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