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Kevetrin 结构式

Kevetrin

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货号 :BCP28785CAS号 :500863-50-3纯度:98%
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  • 基本信息与产品描述
CAS号 500863-50-3 货号 BCP28785
中文名 Kevetrin
英文名 Kevetrin
中文别名
英文别名 Thioureidobutyronitrile; Thioureido butyronitrile;
SMILES NC(SCCCC#N)=N
化学名称
分子式 C5H9N3S 分子量 143.21
纯度 98% 配送 惯例下常温包邮
产品描述 Kevetrin ( thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Upon intravenous administration, thioureidobutyronitrile activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Thioureidobutyronitrile may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. ).
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