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| CAS No. | 502632-66-8 | Cat. No. | BCP27666 |
| Name | Sonolisib | ||
| Synonyms | PX 866;PX866;PX-866; | ||
| SMILES | CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C(=CN(CC=C)CC=C)C4=C(C3=O)O)COC)C)C | ||
| Chemical Name | |||
| Formula | C29H35NO8 | M. Wt | 525.59 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Sonolisib, also known as PX-866, is a small-molecule wortmannin analogue inhibitor of the alpha, gamma, and delta isoforms of phosphoinositide 3-kinase (PI3K) with potential antineoplastic activity. PI3K inhibitor PX-866 inhibits the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. | ||
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