Prima-1
Data Sheet
For research use only. Not for human use.
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| CAS No. | 5608-24-2 | Cat. No. | BCP26191 |
| Name | Prima-1 | ||
| Synonyms | 2,2-Bis(Hydroxymethyl)-3-Quinuclidinone; 2,2-Dimethylolquinuclidin-3-One; | ||
| SMILES | O=C1C(CO)(CO)N2CCC1CC2 | ||
| Chemical Name | |||
| Formula | C9H15NO3 | M. Wt | 185.22 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PRIMA-1, named for p53 reactivation and induction of massive apoptosis, is an inhibitor of the growth of cell lines derived from various human tumor types in a mutant p53-dependent manner. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations. It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. | ||
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