PKR Inhibitor New
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| CAS No. | 608512-97-6 | Cat. No. | BCP30785 |
| Name | PKR Inhibitor | ||
| Synonyms | GW-506033X; GW 506033X; GW506033X; C16;RNA-Dependent Protein Kinase Inhibitor; | ||
| SMILES | C1=CC2=C(C3=C1NC(=O)C3=CC4=CN=CN4)SC=N2 | ||
| Chemical Name | |||
| Formula | C13H8N4OS | M. Wt | 268.29 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PKR Inhibitor, also known as GW-506033X or C16. C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. GW-506033X protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress. PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. PKR inhibitor C16 binds efficiently with human microtubule affinity-regulating kinase 4. | ||
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