Paroxetine maleate New
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| CAS No. | 64006-44-6 | Cat. No. | BCP29366 |
| Name | Paroxetine maleate | ||
| Synonyms | Paroxetine maleate salt；FG 7051 maleate; | ||
| SMILES | C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.C(=CC(=O)O)C(=O)O | ||
| Chemical Name | |||
| Formula | C19H20NO3F.C4H4O4 | M. Wt | 445.44 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Paroxetine maleate is a maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo. It has a role as an antidepressant, an anxiolytic drug, a serotonin uptake inhibitor, a hepatotoxic agent and a P450 inhibitor. It contains a paroxetinium(1+). | ||
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