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CAS号 | 66592-89-0 | 货号 | BCP16345 |
中文名 | Kevetrin hydrochloride | ||
英文名 | Kevetrin hydrochloride | ||
中文别名 | |||
英文别名 | 4-Isothioureidobutyronitrile hydrochloride;Thioureidobutyronitrile hydrochloride;Thioureido butyronitrile hydrochloride; | ||
SMILES | |||
化学名称 | |||
分子式 | C5H10ClN3S | 分子量 | 179.67 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area. |
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