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Kevetrin hydrochloride 结构式

Kevetrin hydrochloride

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货号 :BCP16345CAS号 :66592-89-0纯度:98%
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  • 基本信息与产品描述
CAS号 66592-89-0 货号 BCP16345
中文名 Kevetrin hydrochloride
英文名 Kevetrin hydrochloride
中文别名
英文别名 4-Isothioureidobutyronitrile hydrochloride;Thioureidobutyronitrile hydrochloride;Thioureido butyronitrile hydrochloride;
SMILES
化学名称
分子式 C5H10ClN3S 分子量 179.67
纯度 98% 配送 惯例下常温包邮
产品描述 in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area.
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