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瀚香生物(Biochempartner)的Galunisertib被文献引用
| CAS号 | 700874-72-2 | 货号 | BCP02173 |
| 中文名 | Galunisertib | ||
| 英文名 | Galunisertib | ||
| 中文别名 | |||
| 英文别名 | LY2157299; LY-2157299; LY 2157299; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C22H19N5O | 分子量 | 369.42 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | LY2157299 potently inhibits the TGFβ receptor signaling. LY2157299 abolishes the TGFβ induced Smad2 phosphorylation in HUVEC cells. LY2157299 also shows dose dependent potentiation of VEGF or bFGF induced cell proliferation in HUVEC. LY2157299 also promotes VEGF induced HUVEC cell migration. LY2157299 potentiates angiogenesis in the in vitro VEGF-stimulated cord formation assay. LY2157299 inhibits TGF-β-mediated SMAD2 activation and hematopoietic suppression in primary hematopoietic stem cells in a dose-dependent manner. LY2157199 treatment stimulates hematopoiesis from primary MDS bone marrow specimens.In human glioblastoma (GBM) cells, LY2157299 treatment blocks signaling through the heteromeric TGFβ receptor complex to reduce levels of active, phosphorylated SMAD. | ||
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