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CAS No. | 801-52-5 | Cat. No. | BCP38467 |
Name | Porfiromycin | ||
Synonyms | Regamycin;Methylmitomycin;N-Methylmitomycin C;Methyl mitomycin C; | ||
SMILES | CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4C)N | ||
Chemical Name | |||
Formula | C16H20N4O5 | M. Wt | 348.35 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Porfiromycin is an N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. |
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