GSK269962 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP27824CAS No. ：850664-21-0Purity：98%

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CAS No.	850664-21-0	Cat. No.	BCP27824
Name	GSK269962
Synonyms	GSK269962; GSK-269962; GSK269962A; GSK 269962A; GSK-269962A; GSK269962B;
SMILES	CCN C2=CC(=NC=C2N=C1C3=N
Chemical Name
Formula	C29H30N8O5	M. Wt	570.6
Purity	98%	Storage	Store at 4-8°C
Description	GSK 269962 is a potent ROCK inhibitor with IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively, which displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. It may be used in OAB treatment. It has been shown to block the generation of inflammatory cytokines in lipopolysaccharide-stimulated monocytes and to induce vasorelaxation in preconstricted rat aorta (IC50 = 35 nM). It lowers blood pressure in a rat model of hypertension. It induced a reduction in blood pressure of approximately 10, 20, and 50 mm Hg at doses of 1, 3, and 30 mg/kg. It represent a novel class of ROCK inhibitors that have profound effects in the vasculature, which may enable us to further evaluate the potential beneficial effects of ROCK inhibition in animal models of cardiovascular as well as other chronic diseases.