Letaxaban

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP24734CAS No. ：870262-90-1Purity：98%

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CAS No.	870262-90-1	Cat. No.	BCP24734
Name	Letaxaban
Synonyms	TAK 442; TAK442;TAK-442;
SMILES
Chemical Name
Formula	C22H26ClN3O5S	M. Wt	479.98
Purity	98%	Storage	Store at 4-8°C
Description	Letaxaban, also known as TAK-442, is a potent, selective, and orally active factor Xa inhibitor, which is a tetrahydropyrimidin-2(1H)-one derivative. TAK-442 inhibited endogenous FXa activity in platelet-poor human [half-maximal inhibitory concentration (IC(50)): 53 nM, TAK-442 ] and rat (IC(50): 32 nM, TAK-442 ) plasma. TAK-442 inhibited in vitro reconstituted human prothrombinase (system included FXa, calcium, and washed platelets) with an IC(50) value of 51 nM. In a rat model of balloon injury, thrombin activity on the surface of injured vessels increased to 3.2-, 22-, and 5.8-fold the activity on the surface of the intact aorta at 5 minutes, 1 hour, and 24 hours after the injury, respectively. At approximately 1 hour after the injury, TAK-442 blocked platelet-associated thrombin generation on the surface of injured aortas with an IC(50) value of 19 nM. (source: J Cardiovasc Pharmacol. 2011 Feb;57(2):201-6.)