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Merafloxacin Chemical Structure

Merafloxacin

Data Sheet For research use only. Not for human use.
Cat. No. :BCP42636CAS No. :91188-00-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 91188-00-0 Cat. No. BCP42636
Name Merafloxacin
Synonyms CI 934; CI-934; CI934;
SMILES CCNCC1CCN(C1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CC)F
Chemical Name
Formula C19H23F2N3O3 M. Wt 379.41
Purity 98% Storage Store at 4-8°C
Description Merafloxacin is a fluoroquinolone antibacterial, which was also identified as a −1 PRF inhibitor of SARS-CoV-2. Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on −1 PRF of other beta coronaviruses. Importantly, frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting −1 PRF as an effective antiviral strategy for SARS-CoV-2.
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