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GSK 269962 trihydrochloride Chemical Structure

GSK 269962 trihydrochloride

Data Sheet For research use only. Not for human use.
Cat. No. :BCP26170CAS No. :925213-80-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 925213-80-5 Cat. No. BCP26170
Name GSK 269962 trihydrochloride
Synonyms GSK269962 3HCl; GSK269962 trihydrochloride; GSK269962; GSK 269962; GSK-269962; GSK269962A; GSK 269962A; GSK-269962A; GSK26996B;
SMILES O C(NC1=CC=CC(OC2=CC3=C(N=C(C4=N
Chemical Name
Formula C29H33Cl3N8O5 M. Wt 679.98
Purity 98% Storage Store at 4-8°C
Description GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK-I and ROCK-II, respectively. GSK 269962 could reverse corticosterone-induced depressive-like behaviour and changes in cystometric parameters associated with detrusor overactivity, as well as undo the alterations of several biomarkers related to both disorders (i.e., pro-inflammatory/anti-inflammatory cytokines and neurotrophins) in serum, urinary bladder, and different brain structures.
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