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GSK461364 Chemical Structure

GSK461364

Cat. No. :BCP01720CAS No. :929095-18-1Purity:98%
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Synonyms GSK-461364;GSK 461364
CAS Number 929095-18-1
Purity 98%
M. Wt 543.6
Formula C27H28F3N5O2S
Storage Store at -20°C
GSK461364 inhibits cancer cell line proliferation from multiple origins with minimal toxicity in nondividing human cells. [1] RNA silencing of WT p53 increases the antiproliferative activity of GSK461364. As many cancer therapies tend to be more effective in p53 WT patients, the higher sensitivity of p53-deficient tumors toward GSK461364 could potentially offer an opportunity to treat tumors that are refractory to other chemotherapies as well as early line therapy for these genotypes. GSK461364 i

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