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Ramucirumab Chemical Structure

Ramucirumab

Data Sheet For research use only. Not for human use.
Cat. No. :BCP26258CAS No. :947687-13-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 947687-13-0 Cat. No. BCP26258
Name Ramucirumab
Synonyms LY3009806; IMC-1121B;
SMILES
Chemical Name
Formula C6374H9864N1692O1996S46 M. Wt 6369.07
Purity 98% Storage Store at 4-8°C
Description Ramucirumab is a fully human monoclonal antibody (IgG1). Ramucirumab is a direct VEGFR2 antagonist, that binds with high affinity to the extracellular domain of VEGFR2 and block the binding of natural VEGFR ligands (VEGF-A, VEGF-C and VEGF-D). These ligands are secreted by solid tumors to promote angiogenesis (formation of new blood vessels from pre-existing ones) and enhance tumor blood supply. Binding of ramucirumab to VEGFR2 leads to inhibition of VEGF-mediated tumor angiogenesis.
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