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Beclabuvir Chemical Structure

Beclabuvir

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP11013CAS No. ：958002-33-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 958002-33-0 Cat. No. BCP11013
Name Beclabuvir
Synonyms BMS791325;BMS 791325;BMS-791325;
SMILES CN1CC2CCC(C1)N2C(=O)C34CC3C5=C(C=CC(=C5)OC)C6=C(C7=C(N6C4)C=C(C=C7)C(=O)NS(=O)(=O)N(C)C)C8CCCCC8
Chemical Name
Formula C36H45N5O5S M. Wt 659.84
Purity 98% Storage Store at 4-8°C
Description Beclabuvir, also known as BMS-791325, is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50) below 28 nM. In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. B
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