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Beclabuvir Chemical Structure

Beclabuvir

Cat. No. :BCP11013CAS No. :958002-33-0Purity:98%
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Synonyms BMS791325;BMS 791325;BMS-791325
CAS Number 958002-33-0
Purity 98%
M. Wt 659.84
Formula C36H45N5O5S
Storage Store at 4-8°C
Beclabuvir, also known as BMS-791325, is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50) below 28 nM. In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. B

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