OTS514 hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | OTS514HCl | Cat. No. | BCP28892 |
| Name | OTS514 hydrochloride | ||
| Synonyms | OTS 514 hydrochloride;OTS-514 hydrochloride;OTS514 HCl;OTS-514 HCl;OTS 514 HCl; | ||
| SMILES | O=C1NC2=C(C(C3=CC=C([C@@H](C)CN)C=C3)=C(O)C=C2C)C4=C1SC=C4 | ||
| Chemical Name | |||
| Formula | C21H21ClN2O2S | M. Wt | 400.92 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | OTS514 is a highly potent and selective TOPK inhibitor with IC50 of 2.6 nM; shows selectivity against a panel of 60 kinases (at 0.2 uM, 11.5-18.5% inhibition); strongly suppresses the growth of TOPK-positive cancer cells; demonstrates in vivo efficacy but causes severe hematopoietic toxicity. | ||
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