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TAS6417 HCl Chemical Structure

TAS6417 HCl

Data Sheet For research use only. Not for human use.
Cat. No. :BCP35916CAS No. :TAS6417HClPurity:98%
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  • Chemical Properties&Biological Activity
CAS No. TAS6417HCl Cat. No. BCP35916
Name TAS6417 HCl
Synonyms TAS 6417 HCl;TAS-6417 HCl;
SMILES
Chemical Name
Formula C23H21ClN6O M. Wt 432.91
Purity 98% Storage Store at 4-8°C
Description TAS6417 is a Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations. TAS6417 inhibited EGFR with various exon 20 insertion mutations more potently than it inhibited the WT. TAS6417 inhibited EGFR phosphorylation and downstream molecules in NSCLC cell lines expressing EGFR exon 20 insertions, resulting in caspase activation. These characteristics led to marked tumor regression in vivo in both a genetically engineered model and in a patient-derived xenograft model. Furthermore, TAS6417 provided a survival benefit with good tolerability in a lung orthotopic implantation mouse model.
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