Tiotropium Bromide hydrate is a hydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist. Although tiotropium Bromide (Spiriva; Tiova; BA 679BR; tiopropium) does not display selectivity for specific muscarinic receptors, on topical application tiotropium Bromide (Spiriva; Tiova; BA 679BR; tiopropium) acts mainly on M3 muscarinic receptors located on smooth muscle cells and submucosal glands not to produce smooth muscle contraction and mucus secretion, thus producing a bronchodilatory effect. Tiotropium Bromide (Spiriva; Tiova; BA 679BR; tiopropium) is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease. Tiotropium Bromide (Spiriva; Tiova; BA 679BR; tiopropium) improves symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure. ^[1][2][3]

[1] http://en.wikipedia.org/wiki/Tiotropium_bromide

[2] Kato M et al. Circ J. 2006 Dec; 70(12):1658-60.

[3] Peters SP et al. N Engl J Med. 2010 Oct 28; 363(18):1715-26.