Sotalol (Betapace) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 µM. Sotalol definitely distinctly located binding site to interfere with K+ permeation; both enantiomers associated with a rate close to 5 ? 105 /mol/ sec with the open pore thereby flicker-blocking cardiac K(ATP) channels. ^[1][2]

A relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity.

[1] http://en.wikipedia.org/wiki/Sotalol

[2] Benz I et al. J Membr Biol. 1994 Dec;142(3):309-22.