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Ribavirin is an antiviral drug and a known inhibitor of inositide-5′-monophosphate dehydrogenase.Treatment with Ribavirin resulted in a significant growth inhibition (IC50=15 μM) via activating apoptosis and the differentiation pathway in K562 cells.Nowadays, the reference treatment is combination therapy of pegylated interferon and ribavirin, which is an inosine monophosphate dehydrogenase inhibitor and immunomodulator.
1.Ribavirin Acts via Multiple Pathways in Inhibition of Leukemic Cell Proliferation, Anticancer Res June 2009 29 (6)1971-1980
2.Ribavirin in the Treatment of Hepatitis C , Anticancer Res March 2005 25 (2B)1315-1320