JNJ-7706621 is a novel cell cycle inhibitor that showed potentv inhibition of several cyclin-dependent kinases (CDK) and Aurora kinases and selectively blocked proliferation of tumor cells of various origins but was about 10-fold less effective at inhibiting normal human cell growth in vitro.JNJ-7706621 slowed the growth of cells and at higher concentrations induced cytotoxicity. Inhibition of CDK1 kinase activity, altered CDK1 phosphorylation status,and interference with downstream substrates such as retinoblastoma were also shown in human tumor cells following drug treatment. |
