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No.BCP0453 
Product Name:Mifepristone(Mifeprex) 
Synonyms:RU-486, RU-38486, Mifegyne, Mifeprex 
Cas No.:84371-65-3 

M.Wt: 429.59

Formula: C29H35NO2

Solubility: Unknown

Purity: >99%

Storage: at -20℃ 2 years
 

 

Mifepristone(Mifeprex) is a synthetic steroid compound used as a pharmaceutical. It is used as abortifacient in the first two months of pregnancy, and in smaller doses it is used as an emergency contraceptive. [1]In the presence of progesterone, it acts as a competitive progesterone receptor antagonist (in the absence of progesterone, mifepristone acts as a partial agonist). It is a 19-nor steroid with a bulky p-(dimethylamino)phenyl substituent above the plane of the molecule at the 11β-position responsible for inducing or stabilizing an inactive receptor conformation and a hydrophobic 1-propynyl substituent below the plane of the molecule at the 17α-position that increases its progesterone receptor binding affinity.

1. Jiang W, et al. Bioorg Med Chem, 2006, 14(19), 6726-6732.

2. Goyeneche AA, et al. Clin Cancer Res, 2007, 13(11), 3370-3379.

3. Wang Y, et al. Stem Cells, 2012, 30(2), 169-179.

4. Cabeza M, et al. J Steroid Biochem Mol Biol, 2007, 104(3-5), 321-325.

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