A centrally acting, nonopioid analgesic; flupirtine has a functional profile similar to NMDA-receptor antagonists, but devoid of the typical side effects of these drugs; flupirtine exerts potent cyto- and neuroprotective actions in different in vivo and in vitro models.Non-opioid analgesic with muscle relaxant properties. Activates K⁺ channels and indirectly antagonizes NMDA receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli.

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