Non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 . Prolongs the survival time after MgCl2- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations.

1.AD Kovács and G Szabó. GYKI 53655, a 2,3-benzodiazepine, non-competitively protects cultured neurones against AMPA toxicity. Eur. J. Pharmacol. 1997, 331(1), 93-96.

2.Szabados et al. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405 and GYKI 53655. Brain. Res. Bull. 2001, 55 387.

3.BA Chizh et al. A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord. Br. J. Pharmacol. 1994, 112(3), 843-6.