GSK690693 is an aminofurazan-derived inhibitor of Akt kinases with potential antineoplastic activity. It binds to and inhibits Akt kinases 1, 2, and 3 with IC50 values of 2, 13, and 9 nM respectively, which may result in the inhibition of protein phosporylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In addition, this agent may inhibit other protein kinases including protein kinase C (PKC) and protein kinase A (PKA).

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