Nanomolar concentrations of Flavopiridol hydrochloride inhibited rhabdoid cell growth (IC50-200nmol/L) , induced G1and G2 arrest, and apoptosis in vitro in a concentration-dependent manner. These effects were correlated with the down-modulation of cyclin D1, up-regulation of p21, and induction of caspase 3/7 activities. Flavopiridol (at 7.5 mg/kg) significantly inhibited the growth of xenografted rhabdoid tumors, and its effect was correlated with the induction of p21 and down-modulation of cyclin D1. [1] Exposure of HNSCC cells to flavopiridol diminished cdc2 and cdk2 activity and potently inhibited cell proliferation (IC50=43-83 nM), which was concomitant with the appearance of cells with a sub-G1 DNA content. [2] |
