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ADC Related

Chemical Structure Cat. No. Product Name CAS No.
SPDB Chemical Structure
 BCP33395 SPDB 115088-06-7
SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).
Lys-SMCC-DM1 Chemical Structure
 BCP33031 Lys-SMCC-DM1 1281816-04-3
Lys-SMCC-DM1 is the active metabolite of DM1.
Boc-Val-Cit-PAB-PNP Chemical Structure
 BCP32930 Boc-Val-Cit-PAB-PNP 870487-10-8
Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Vc-MMAD Chemical Structure
 BCP32929 Vc-MMAD 1401963-17-4
Vc-MMAD consists the ADCs linker (Val-Cit) and potent tubulin inhibitor (MMAD). Vc-MMAD is a drug-linker conjugate for ADC.
Microcystin RR Chemical Structure
 BCP32942 Microcystin RR 111755-37-4
Microcystin-RR inhibits PP1C, PP1γ, and PP2A with Ki values of 0.15, 0.24, and 0.018 nM, respectively.
VAL-CIT-PAB-MMAD Chemical Structure
 BCP32931 VAL-CIT-PAB-MMAD 1415329-13-3
VAL-CIT-PAB-MMAD is a drug-linker conjugate for ADC with potent antitumor activity by using Monomethyl Dolastatin 10 (a potent tubulin inhibitor), linked via the ADC linker Vat-Cit-PAB.
CL1-SN-38 Chemical Structure
 BCP32856 CL1-SN-38 1373216-45-5
This ADC product is composed of an anti-CEACAM5 antibody conjuagated via a CL1 linker to SN-38 (CL1-SN-38). It has demonstrated a response in colon carcinoma treatment by a MOA (Mechanism of Action) of Inhibit Topoisomerase I and cause DNA damage.
CL2-SN-38 Chemical Structure
 BCP20816 CL2-SN-38 1036969-20-6
CL2-SN-38 is a part of the antibody drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7.
Dxd Chemical Structure
 BCP32858 Dxd 1599440-33-1
Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
CL2A-SN-38 Chemical Structure
 BCP32728 CL2A-SN-38 1279680-68-0
CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).
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