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ATM/ATR

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ATM/ATR

结构式 货号 产品名称 CAS号
AZD6738 chiral mixtures 结构式
BCP38320 AZD6738 chiral mixtures 1352280-97-7
AZD6738 is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.
(S)-Ceralasertib 结构式
BCP38319 (S)-Ceralasertib 1352226-87-9
(S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics.
AZ32 结构式
BCP37674 AZ32 2288709-96-4
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
BAY-1895344 hydrochloride 结构式
BCP31861 BAY1895344 hydrochloride BAY-1895344HCl
BAY-1895344 hydrochloride is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity.
KU 60019 结构式
BCP30241 KU 60019 925701-46-8
KU-60019 is an improved ATM kinase-specific inhibitor with IC50 of 6.3 nM.
ATR inhibitor 1 结构式
BCP23596 ATR inhibitor 1 1613200-51-3
AZ32 结构式
BCP29590 AZ-32 AZ32
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
AZ-31 结构式
BCP29471 AZ-31 2088113-98-6
AZ-31 is a potent, highly selective and orally active ATM inhibitor with enzyme IC50 of <1.2 nM, cell IC50 of 46 nM.
Mirin 结构式
BCP17184 Mirin 1198097-97-0
Mirin is a small-molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex.
NU 6027 结构式
BCP09221 NU 6027 220036-08-8
NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.
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