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Caspase

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Caspase

Chemical Structure Cat. No. Product Name CAS No.
Z-YVAD-FMK Chemical Structure
BCP23636 Z-YVAD-FMK Z-YVAD-FMK
Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1.
PF03491390 Chemical Structure
BCP07463 PF03491390 254750-02-2
Emricasan (IDN-6556, PF-03491390) is a potent irreversible pan-caspase inhibitor.
MX-1013 Chemical Structure
BCP06742 MX-1013 223568-55-6
EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.
Ginsenoside Rh2 Chemical Structure
BCP23574 Ginsenoside Rh2 78214-33-2
Ginsenoside Rh2 is isolated from the root of Ginseng.
AC-DEVD-CHO Chemical Structure
BCP18451 AC-DEVD-CHO 169332-60-9
Ac-DEVD-CHO is a specific Caspase-3 inhibitor with a Ki value of 230 pM.
Q-VD-OPh Chemical Structure
BCP11954 Q-VD-OPh 1135695-98-5
Q-VD-OPha is a pan-caspase inhibitor with potent antiapoptotic properties.
Z-DEVD-FMK Chemical Structure
BCP07582 Z-DEVD-FMK 210344-95-9
Z-DEVD-FMK is a specific caspase-3 inhibitor with IC50 of 18 μM.
VX-765 Chemical Structure
BCP02893 VX-765 273404-37-8
VX-765 is an orally absorbed prodrug of VRT-043198, which exhibits potent inhibition against ICE/caspase-1 and caspase-4 with Ki of 0.8 nM and less than 0.6 nM, respectively.
Apoptosis Activator 2 Chemical Structure
BCP06746 Apoptosis Activator 2 79183-19-0
Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.
PAC-1 Chemical Structure
BCP02892 PAC-1 315183-21-2
PAC 1 is a procaspase-activating compound, which in turn produces caspase-3 (EC50 = 0.22 μM). PAC 1 also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). This compound is a proapoptotic, inducing apoptosis in both cancerous and non-cancerous cell lines.
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