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CCR

结构式 货号 产品名称 CAS号
AZD-5672 结构式
BCP48543 AZD-5672 780750-65-4
AZD-5672 is an orally active, potent, selective CCR5 antagonist. AZD-5672 shows moderate activity against the hERG ion channel. AZD5672 is used for the research of rheumatoid arthritis.
K-11777 结构式
BCP48070 K-11777 233277-99-1
K-11777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively.
INCB3344 结构式
BCP35107 INCB3344 1262238-11-8
INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.
CCR3 antagonist 1 结构式
BCP45725 CCR3 antagonist 1 879399-82-3
CCR3 antagonist 1 is a potent antagonist of CCR3, used for the research of immunologic and inflammatory diseases.
CCR3 Antagonist 结构式
BCP44858 CCR3 Antagonist 275812-32-3
AZD-4818 结构式
BCP44354 AZD-4818 1003566-93-5
AZD-4818 is a chemokine CCR1 antagonist that is used for the treatment of chronic obstructive pulmonary disease.
Nifeviroc 结构式
BCP39005 Nifeviroc 934740-33-7
Nifeviroc is a CCR5 antagonist potentially for treatment of inflammatory responses to HIV type-1 infection
R243 结构式
BCP37891 R243 688352-84-3
R243 is an inhibitor of CCR8 signaling and chemotaxis.
TAK-220 结构式
BCP37344 TAK-220 333994-00-6
TAK-220 is an orally bioavailable small-molecule CCR5 antagonist
TAK-220 Hydrochloride 结构式
BCP37346 TAK-220 Hydrochloride 674782-27-5
TAK-220 is a selective and orally bioavailable CCR5 antagonist.
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