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CDK

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CDK

Chemical Structure Cat. No. Product Name CAS No.
MC180295 Chemical Structure
BCP31053 MC180295 2237942-08-2
MC180295 is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC50 of 5 nM, at least 22-fold more selective for CDK9 over other CDKs. MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect.
CDK8-IN-1 Chemical Structure
BCP23512 CDK8-IN-1 1629633-48-2
CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.
CT7001 hydrochloride Chemical Structure
BCP30944 CT7001 hydrochloride 1805789-54-1
CT7001 hydrochloride is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively.
ON-013100 Chemical Structure
BCP17288 ON-013100 865783-95-5
ON-013100, an antineoplastic drug, acts a mitotic inhibitor that could inhibit Cyclin D1 expression.
ABC-1183 Chemical Structure
BCP30547 ABC-1183 1042735-18-1
ABC-1183 is a selective dual GSK3α/β and CKD9 inhibitor.
SEL120-34A Chemical Structure
BCP30533 SEL120-34A 1609522-33-9
SEL120-34A is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.
BSJ-03-123 Chemical Structure
BCP30504 BSJ-03-123 BSJ-03-123
BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader (PROTAC).
dBET6 Chemical Structure
BCP30500 dBET6 1950634-92-0
dBET6 is a novel degrader of BET bromodomain proteins. dBET6 prompts a collapse of global elongation that phenocopies CDK9 inhibition.
Atuveciclib Racemate Chemical Structure
BCP30202 Atuveciclib Racemate 1414943-88-6
Atuveciclib Racemate is the racemate mixture of BAY-1143572. BAY-1143572 is a potent and highly selective, oral P-TEFb/CDK9 inhibitor which supresses CDK9/CycT1 with an IC50 of 13 nM.
CDK4-IN-1 Chemical Structure
BCP12704 CDK4-IN-1 1256963-02-6
CDK4-IN-1 is a selective inhibitor of cyclin-dependent kinase 4.
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