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CDK

结构式 货号 产品名称 CAS号
Abemaciclib Metabolites M2 结构式
BCP42813 Abemaciclib Metabolites M2 1231930-57-6
Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor (IC50s: 1-3 nM) with anti-cancer activity.
CDK4/6/1 Inhibitor 结构式
BCP43972 CDK4/6/1 Inhibitor 2099128-41-1
CDK4/6/1 Inhibitor is a CDK4/6 inhibitor. It is a potent anti-proliferative agent that arrests U87MG cell line exclusively in G1.
CLK-IN-T3 结构式
BCP43827 CLK-IN-T3 2109805-56-1
CLK-IN-T3 is a pan-CLK inhibitor, CLK-IN-T3 as well as the negative control T3-CLK-N have been developed in collaboration with Takeda 3 (5).
Indirubin-3'-oxime 结构式
BCP43705 Indirubin-3'-oxime 667463-82-3
Indirubin-3'-monoxime, a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes.
PF07104091 结构式
BCP42948 PF07104091 2460249-19-6
PF-07104091 is an orally bioavailable inhibitor of cyclin-dependent kinase 2 (CDK2), with potential antineoplastic activity.
LY3405105 结构式
BCP42676 LY3405105 2326428-25-3
LY3405105 is an orally active CDK7 inhibitor with an IC50 of 92.8 nM. LY3405105 shows potential antineoplastic activity.
MS140 结构式
BCP42677 MS140 2229974-83-6
MS140 is a specific and highly potent CDK4/6 kinase inhibitor and also a CDK4/6 degrader (PROTAC).
SB1317 结构式
BCP42651 SB1317 1204918-72-8
SB1317 is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. Zotiraciclib may be useful for the treatment of cancer that crosses the blood brain barrier and acts by depleting Myc through the inhibition of cyclin-dependent kinase 9 (CDK9). It is one of a number of CDK inhibitors under investigation; others targeting CDK9 for the treatment of acute myeloid leukemia include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, with 80 percent of glioblastomas characterized by this property.
CDK4 inhibitor compound 12 结构式
BCP41586 CDK4 inhibitor compound 12 2105956-77-0
CDK4 inhibitor compound 12 is a novel inhibitor of CDK4 with the activity 97 μM.
KB-0742 结构式
BCP41310 KB-0742 2416873-83-9
KB-0742 is an orally bioavailable, selective CDK9 inhibitor with potent anti-tumor activity in CRPC models.
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